The scientists attached normal mice, which don’t naturally develop Alzheimer’s disease, to mice modified to carry a mutant human gene that produces high levels of the protein called amyloid beta.
Alzheimer’s disease, the leading cause of dementia, has long been assumed to originate in the brain but new research indicates that it could be triggered by breakdowns elsewhere in the body.
https://news.ubc.ca/2017/10/31/alzheimers-disease-might-be-a-whole-body-problem/